Epigenetics is the study of changes in gene activity that do not involve direct alterations to the actual genetic code. There is a relationship between genes and traits, and the bridge between the gene or genes underlying a trait is a protein. Genes are the code for building proteins, and once built, proteins carry about many functions in the body and they are ultimately responsible for behavioral traits. How is it decided what specific genes get turned on or off? The patterns oepi-f gene expression (protein manufacture) are governed by the cellular material—the epigenome—that sits on top of the genome, just outside it (hence the prefix , which means “above”). It is these epigenetic “marks” that tell certain genes to switch on or off. It is through epigenetic marks that environmental factors like diet, stress, and prenatal nutrition can make an imprint on genes, and this imprint can be passed on over generations. With epigenetic changes, the DNA itself does not change, but the way individual genes within the sequence are expressed (or turned on or off) does change.
Read about gene-by-environment effects (also called gene x environment or G X E) in the Champagne and Mashoodh (2009) article. The particular example you will examine is epigenetic programming due to variations in maternal care. Specifically, in rodent models, it was found that maternal behavior such as carefully licking and grooming the pups was tied to a decreased stress response and lower levels of exploration fear in the pups. Mothers that displayed low levels of pup licking and grooming had adult offspring with a heightened stress response. This study provided evidence that epigenetic changes can underlie the long-term impact of early life experiences.
For this paper, consider the personal and social implications of gene x environment interactions. Also consider other gene x environment interactions future research will be most likely to discover based on your introduction to this new topic.
With these thoughts in mind:
Post your response to the following:
Explain how epigenetics provides a new perspective on the nature versus nurture debate. Also, reference the Champagne and Mashoodh (2009) article, and provide an explanation of how the rat-nurturing example can further explain human parental behavior. In addition, explain the broader social implications of this type of research. Finally, share your prediction of and rationale for what other gene x environment interactions future research may discover. (atleast 750 words)
Document: Expanding our understanding of social change: A report from the definition task force of the HLC special emphasis project (PDF).Callahan, D., Wilson, E., Birdsall, I., Estabrook-Fishinghawk, B., Carson, G., Ford, S., Yob, I. (2012).Minneapolis, MN: Walden University.
Champagne, F. A., & Mashoodh, R. (2009). Genes in context: Gene-environment interplay and the origins of individual differences in behavior.Current Directions in Psychological Science, 18(3), 127–131.Note: Retrieved from Walden Library databases.
Roth, T. L., & Sweatt, J. D. (2011). Annual research review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development.Journal of Child Psychology and Psychiatry, 52(4), 398–408.Note: Retrieved from Walden Library databases.
TED Conferences, LLC (Producer). (2012).Epigenetics makes you unique [Video file]. Retrieved fromNote: The approximate length of this media piece is 18 minutes.
Santavirta, T., Santavirta, N., Gilman, S. (2018).Association of the World War II Finnish Evacuation of Children With Psychiatric Hospitalization in the Next Generation. JAMA Psychiatry. 2018;75(1):21-27 Retrieved from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC58335…
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